Hong‐Duo Chen
Chinese Journal of Aesthetic Medicine · 2009
Abstract
Objective To investigate the protective effects of resveratrol on the back skin irradiated by solar simulator ultraviolet irradiation(ssUVR).Methods Eleven healthy volunteers were enrolled in this study.Six sites on the nonexposed back skin were marked for the experiment.Sites 1～4 were applied with resveratrol+antioxidant,antioxidant,resveratrol,base cream,and followed by ssUVR at a dosage of 1.5 minimal erythema dose 30 min later.Site 5 received ssUVR but without any test materials(i.e.positive control)and site 6 received neither ssUVR nor test materials(i.e.negative control).L value,a* value and b* value were assessed pre-and after-irradiation.Results On negative control site,no erythema was observed and L a* value were 63.76 7.10.On positive control and base-treated sites,obvious erythema was developed,L values obviously decreased to 56.10 and 56.38 respectively,and a* values significantly increased to 15.55 and 15.97 respectively.Whereas on resveratrol and antioxidant-treated site,only slightest erythema was seen,L a* reached 59.32 12.96 with the least changes comparing to other irradiated sites.Conclusions Combination of resveratrol and antioxidant was essential for protection against ssUVR-induced damage.