Risk factors for variation in 25-hydroxyvitamin D₃ and D₂ concentrations and vitamin D deficiency in children.

Tolppanen AM, Fraser A, Fraser WD, Lawlor DA.

The Journal of clinical endocrinology and metabolism · 2012

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Abstract

Context Vitamin D status is believed to be best indicated by serum 25-hydroxyvitamin D [25(OH)D; consisting of 25(OH)D₃ and 25(OH)D₂] that are obtained from different sources. Suboptimal vitamin D status is common and associated with adverse health outcomes. Objectives The objectives were to report the prevalence and risk factors of vitamin D deficiency and determine associations of characteristics that have been shown to relate to total 25(OH)D with 25(OH)D₃ and 25(OH)D₂ concentrations. Design and setting The Avon Longitudinal Study of Parents and Children is a population-based contemporary birth cohort (children born in 1991-1992) from southwest England. Participants and outcome measures Seven thousand five hundred sixty children with serum 25(OH)D₃ and 25(OH)D₂ concentrations measured at the mean age of 9.9 yr participated in the study. Results Vitamin D deficiency [total 25(OH)D concentration Conclusions Vitamin D deficiency was common in this contemporary U.K. cohort. Despite some overlap, there are differences in potential confounding structures for associations of 25(OH)D₃ and 25(OH)D₂ with health outcomes. These should be accounted for in future studies.